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KMID : 0928320090090020135
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Korean Journal of Health Promotion and Disease Prevention
2009 Volume.9 No. 2 p.135 ~ p.141
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Effects of 12-week Aerobic Exercise on the Metabolic Syndrome Factors Dependent on UCP2 Gene Polymorphism in Middle-Aged, Obese Women
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Kim Ji-Seok
Shin Yun-A
Seo Dong-Il
Chang Hyuk-Ki
Jun Tae-Won
Song Wook
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Abstract
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Background: The aim of this study was to investigate the effects of 12 weeks of aerobic exercise on the metabolic syndrome factors dependent on UCP2 gene polymorphismin middle-aged, obese omen.
Methods: A total of 34 healthy, obese women were recruited and classified according to UCP2 gene I/D polymorphism (ID, n=17; DD, n=17; middle-aged). Anthropometry (body weight, height, BMI and % body fat) and the metabolic syndrome factors(waist circumference, blood pressure, triglyceride, HDL-cholesterol and fasting blood glucose) were measured before and after the intervention. The
exercise groups of each polymorphism group trained on the treadmill at an intensity of 60%VO2R for one hour every other day except weekends for 12 weeks.
Results: Although there were significant 12-week aerobic exercise effects in body weight, BMI, VO2max, waist circumference and SBP, there was no significant exercise effects among UCP2 genotypes on the components of metabolic syndrome factors. However, WHR decreased significantly from 0.85 to 0.80 (p=.016), and % body fat dropped from 34.7% to 32.7% (p=.054) in the ID genotype while the DD genotype had no significant influence.
Conclusions: In comparing the effects of exercise on metabolic syndrome factors according to the UCP2 genotypes, there was no significant difference between ID heterozygotes and DD homozygotes. However, this study showed that ID UCP2 genotype has more exercise effects on abdominal obesity-related factors (WHR and % body fat).
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KEYWORD
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uncoupling protein, metabolic syndrome, obesity, aerobic exercise
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